Here's a page for people to add questions they think SHOULD show up on Exam I. Exam questions should be multiple choice/multiple answer, short answer, or picture & labels. No need to post which answers are right (even though the rest of the class would enjoy that!)

1. The myeloid lineage contains which cells?
a. Acquired immune cells
b. T cells
c. Neutrophils
d. Eosinophils
e. Innate immune cells
answers: c,d,e

2. Antimicrobial peptides are?
a. Opsonins
b. Short proteins
c. Cationic and amphipathic
d. Released by granulocytes
e. Capable of killing self cells at high concentrations
answer: b, c, d, e

3. Describe the Alternative Pathway of the complement cascade if it was NOT activated by random cleavage on the surface of a microbe. (How is it activated, what happens when activated?) Sorry, I meant to ask about Lectin Pathway if MBL did not bind to mannose without prior stimulation. The answer I was thinking of would be something along the lines of after the classical pathway cascade had begun, C3a and C5a act as proinflammatory mediators, and an increase in MBL levels are seen, which would then be capable of binding to mannose. Once mannose was bound by MBL, MBL would act in place of C1 and would cleave C2 and C4. The rest of the pathway is the same as the classical pathway.

4. What are the differences between Bacteria and Viruses?
a. Viruses require a host cell to replicate.
b. Bacteria can be pathogens.
c. Viruses are prokaryotes.
d. Bacteria have a membrane.

5. Which of the following are characteristics of the innate immune system?
a. Innate immune pathways are very conserved.
b. Exposure to pathogens protects you when re-exposed to pathogen.
c. You are born with it.
d. Causes inflammation

6. What are the similarities between phagocytosis and macropinocytosis?
a. Phagocytosis requires actin cytoskeleton rearrangement.
b. Macropinocytosis engulfs stuff.
c. Macropinocytosis is receptor mediated.

7. CD4 T-Cells?
a. are called cytotoxic T cells. Answers b c
b. Interact with MHC II
c. aid in killing extracellular pathogens
d. is part of innate immunity

8. What is the difference between primary lymphoid tissue and secondary lymphoid tissue?
a. T and B cells are both found in primary tissue
b. secondary is where antigens are introduced to T and B cells answers b c
c. MALT is a type of the secondary tissue
d. denridic cells are required for proper function primary tissue.

9. Follicular dendridic cells…
a. are antigen presenting cells
b. circulate in the blood Answers a c
c. are of epithelial linneage
d. live in hair follicles

10. What are characteristics of Complement from below?
a. amplifies inflammatory response
b. does not undergo opsonization of microbes
c. formation of membrane attack complex (MAC) Answers: a, c, d
d. works with acquired immunity

11. Types of macrophages
a. circulating
b. eosinophils
c. granulocytes Answers: a, d
d. resident

12. Distinct features the innate immune system recognizes on microbes are:
a. LTA
b. LPS
c. Chemokines
d. Peptidoglycan Answers: a, b, d

13. The human body has many defenses against microbes. Give two specific examples of microbes that have mechanisms to defend them against our immune system. (Feel free to edit answers into this space)

14. Which of the following contain antimicrobial peptides?
a. Epithelial cells of alveoli
b. Granules of eosinophils
c. Paneth cells (crypt of sm. intestine)
d. Dendritic cells Answer: a, b, c

15. What are the difference between the Lectin Complement Pathway and the Classical Complement Pathway?
a. C4b and C2b form the C3 convertase
b. MBL bind to mannose
c. C1 cleaves C2 into C2a and C2 b
d. C6, C7 C8 recuit lots of C9
answer b, c

16. Which lineage do dendritic cells come from?
a. lymphoid lineage
b. Myeloid lineage
c. erythroid lineage
d. megakaryocyt lineage
answer: a, b

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